Haemophilus influenzae
    - Introduction
    - Aims
    - Vaccine schedules
    - Data
    - Participants

Type of Hib conjugate vaccine and immunisation schedule used in the study participants countries, as at March 2004

Australia Germany Norway

Austria Greece Netherlands

Belgium Iceland Portugal

Czech Republic Ireland Spain

Denmark Israel Sweden

Finland Italy United Kingdom

France Malta

AUSTRALIA

Year Pre 2001 2002

Type of vaccine HbOC (95%) Pedvax Hib 5 states

Combined with DTPa, HepB, OPV

Immunisation schedule 2, 4, 6, 18 months 2, 4, 12 months

Type of vaccine PRP-OMP (5%) PRP-OMP (Comvax) 3 states

Combined with Hep B

Immunisation schedule 2, 4, 12 months 2, 4, 12 months

AUSTRIA

Year 2000, 2001 2001 2002, 2003 2004

Type of vaccine Infanrix + Hib (SKB) Hexavac (DTaP-Hib-IPV-HBV) Infanrix + Hib (SKB) Infanrixa hexa (GlaxoSmithKline)

Combined with DTaP DTaP, IPV, HBV DTaP, IPV DT-PEA, IPV, HB

Immunisation schedule 3, 4, 5 months & 2nd year of life 3, 4, 5 months & 2nd year of life 3, 4, 5 months & 2nd year of life 3, 4, 5 months & 2nd year of life

Type of vaccine Infanrix-IPV + Hib (SKB) Procomvax Hexavac
(Aventis Pasteur MSD)

Combined with DTaP, IPV HBV DT-PEA, IPV, HB

Immunisation schedule 3, 4, 5 months & 2nd year of life 3, 4, 5 months & 2nd year of life 3, 4, 5 months & 2nd year of life

Type of vaccine Procomvax (A. P. MSD)*

Combined with HBV

Immunisation schedule 3, 4, 5 months & 2nd year of life

BELGIUM

Year 2003 2004

Type of vaccine Hib-PRP-T (Hiberix & Act-Hib) Infanrix hexa (GSK)

Combined with Not combined DtaP, IPV, HBV

Immunisation schedule 2, 3, 4 mths & 13-18 months 2,3,4 mths & 13-18 mths

Type of vaccine Hib-HBOc

Combined with Not combined

Immunisation schedule 2, 3, 4 mths & 13-18 months

CZECH REPUBLIC

Year July 2001

Type of vaccine Hib-PRP-T (TETRACTHIB)

Combined with DTwP

Immunisation schedule 2, 3, 4 mths & 18-20 mths

DENMARK

Year June 1993 - 1995 1996 1997 - 2002 July 2002

Type of vaccine PRP-T (Act-HIB Pasteur Merieux) PRP-T (Act-HIB Pasteur Merieux) PRP-T (Act-HIB Pasteur Merieux) PRP-T (Act-HIB Pasteur Merieux)

Combined with Not combined Not combined Not combined DTaP-IPV/HIB

Immunisation schedule 5, 6, 16 months 5, 6, 15 months 3, 5, 12 months 3, 5, 12 months

FINLAND

Year 1993 1994 - Sept 2002 October 2002

Type of vaccine Act-Hib (Pasteur Merieux) HibTITER (Wyeth-Lederle) Hiberix (GSK)

Combined with Combined with DTwP Not combined Not combined

Immunisation schedule 4, 6 & 14-18 months 4, 6 & 14-18 months 4, 6 & 14-18 months

FRANCE

Year 1993 1998 2002 2003

Type of vaccine Hib PRP-T (Pentacoq, Pent hibest) Hib PRP-T(Pentacoq, Pent hibest) Hib PRP-T (Pentacoq) Pentavac Hib-PRP-T (Hexavac)

Combined with DTwP, IPV DTwP, DTaP, IPV DTwP, DTaP, IPV DTwP,DTaP, IPV, HepB

Immunisation schedule 2, 3, 4, 18 months 2, 3, 4, 18 months 2, 3, 4, 18 months 2, 4, 18 months (vaccine with 5 antigens at 3 months of age)

Type of vaccine Pentavac Pentavac

Combined with

Immunisation schedule 18 months 2, 3, 4, 18 months

Type of vaccine Infanrix Polio Hib Infanrix Polio Hib

Combined with

Immunisation schedule 18 months 2, 3, 4, 18 months

GERMANY

Year 1992, 1993 Since 1996 1997, 1998 1999 Since 2001, 2002

Type of vaccine Hib-PRP-T-CRM197 (HibTiter/Wyeth Lederle) Hib-PRP OMPC (Pedvax Hib liquid/Chiro Behring) Hib-PRP-T (Infanrix-IPV+Hib/GSK; Pentavac/Aventis Pasteur MSD) Hib PRP-OMPC (Procomvax/Aventis Pasteur MSD) Hib-PRP-T (Infanrix-Hexa/GSK; Hexavac/Aventis Pasteur MSD)

Combined with Not combined Not combined DtaP-IPV Hep B DtaP-IPV-HBV

Immunisation schedule 2, 4 months, plus 11-14 months 2, 3, 4 months, plus 11-14 months# 2, 4 months, plus 11-14 months# 2, 4 months, plus 11-14 months 2, 3, 4 months, plus 11-14 months

Type of vaccine* Hib-PRP-T (Act-HIB/Aventis Pasteur MSD) Hib-PRP-T (Infanrix+Hib/GSK)

Combined with Not combined DTaP

Immunisation schedule 2, 4 months, plus 11-14 months 2, 3, 4 months, plus 11-14 months#

  Mono-vaccines are not available at the moment, March 2004
  # Given at least 4 weeks apart with a minimum of 6 months between dose (11-14 month dose) and previous dose.

GREECE

Year 1999 2003

Type of vaccine PRP-T HbOC PRP-T (Act-Hib, Hiberix)

Combined with DTaP, IPV DtaP, IPV, Hep B

Immunisation schedule 2, 4, 6, 18 months 2, 4, 6, 15-18 months

Type of vaccine HbOC (Hibtiter)

Combined with Not combined

Immunisation schedule 2, 4, 6, 15-18 months

Type of vaccine HibOMP (Procomvax)

Combined with Hep B

Immunisation schedule On special occasions, by case

HUNGARY

Year 1999 2006

Type of vaccine PRP-T PRP-T

Combined with DTP, OPV at 4, 5 months
MMR, OPV at 15 months DTP, IPV

Immunisation schedule 4, 5, 15 months 2, 3, 4, 18 months

ICELAND

Year 1989 Jan 2002

Type of vaccine PRP-D ProHIBit PRP-T (Pentavac)

Combined with DTaP, IPV DTaP, IPV

Immunisation schedule 3, 4, 6, 14 months 3, 5, 12 months

IRELAND

Year Pre August 2001 Post August 2001 2002 2004

Type of vaccine PRP-T (ACTHib or HibTITRE(60%), Hiberix (30%)) PRP-T (Pentavac) 100% PRP-T (Infanrix-HIV+Hib) (70%)
PRP-T (Pentavac) (30%) PRP-T (Infanrix-IPV+Hib) (75-80%)
PRP-T (Pentavac) (20-25%)

Combined with DTaP, IPV DTaP, IPV DTaP, IPV

Immunisation schedule 2, 4, 6 months 2, 4, 6 months 3, 2, 4, 6 months 2, 4, 6 months

ISRAEL

Year 1994 - 1997 July 1997 1999 May 2002

Type of vaccine PRP-OMP (90%) PRP-T PRP-T PRP-T

Combined with DTwP DTaP, IPV

Immunisation schedule 2, 4, 12 months 2, 4, 6, 12 months 2, 4, 6, 12 months 2, 4, 12 months

Type of vaccine HbOC/PRP-T (10%) HbOC plus PRP-T

Combined with DTwP plus DTaP

Immunisation schedule 2, 4, 6, 12 months 2, 4, 6, 12 months 6 months

ITALY

Year 1995 to March 1999 April 1999 2000 2001

Type of vaccine PRP-T PRP-T

Combined with Not combined Not combined

Immunisation schedule <6 months (3 doses + booster)
6-12 (2 doses + booster)
>12 months (1 dose) 3, 5, 11-12 months

Type of vaccine HbOC* HbOC

Combined with Not combined Not combined

Immunisation schedule <6 months (3 doses + booster)
6-12 (2 doses + booster)
>12 months (1 dose) 3, 5, 11-12 months

Type of vaccine PRP-T plus OMP plus PRP-T

Combined with DTaP, IPV plus HepB plus DTaP, IPV, HepB

Immunisation schedule 3, 5, 11-12 months 3, 5, 11-12 months 3, 5, 11-12 months

  * not available in 1997

MALTA

Year 1995

Type of vaccine PRP-T (Aventis Pasteur MSD)

Combined with DwTP, OPV

Immunisation schedule 2, 3, 4 months

NETHERLANDS

Year Pre 1999 1999 2003 2005

Type of vaccine PRP-T PRP-T Hib-PRP-T Hib-PRP-T

Combined with DTP (in other limb) DTwP, IPV DPaP, IPV

Immunisation schedule 3, 4, 5, 11 months 2, 3, 4, 11 months 2, 3, 4, 11 months 2, 3, 4, 11 months

NORWAY

Year 1992 - 1998 1998 - 2001 2001

Type of vaccine PRP-T (Act-Hib) PRP-T (Act-Polio) PRP-T (Infanrix-Polio+Hib)

Combined with DTwP (in other limb) IPV (DTaP in other limb) DTaP, IPV

Immunisation schedule 3, 5, 10 months 3, 5, 10 months 3, 5, 11-12 months

PORTUGAL

Year 2000 - 2001 2002 2003

Type of vaccine HbOC (Hibtiter) HbOC (Hibtiter) PRP-T (Hiberix)

Combined with Not combined Not combined Not combined

Immunisation schedule 3, 5, 10 months 3, 5, 10 months 3, 5, 11-12 months

Type of vaccine PRP-T (Tetract-Hib) PRP-T (Tetrat-Hib)

Combined with DTwP DTwP

Immunisation schedule 2, 4, 6, 15-18 months 2, 4, 6, 15-18 months

SPAIN

Year 2002, 2003

Type of vaccine Hib-PRP-T (Act-Hib: Hiberix

Combined with Not combined

Immunisation schedule 2, 4, 6, 15-18 months

Type of vaccine Hib-PRP-T (Infanrix Hib)

Combined with DTaP

Immunisation schedule 2, 4, 6, 15-18 months

Type of vaccine Hib-PRP-T (Tetract-Hib)

Combined with DTwP

Immunisation schedule 2, 4, 6, 15-18 months

Type of vaccine Hib-PRP-T (Pentact-Hib)

Combined with DRwP, IPV

Immunisation schedule 2, 4, 6, 15-18 months

SWEDEN

Year 1992 to 1993 1993 - 1995 1996 to 1997 1998 - 1999 2000

Type of vaccine PRP-OMP (PedvaxHIB) or PRP-T (Act-Hib) PRP-T (Act-Hib) PRP-T (Act-Hib) PRP-T (Act-Hib or Pentavac) PRP-T (Pentavac or Infanrix-Polio+Hib)

Combined with DT separately, IPV separately or mixed with PRP-T DT separately, IPV separately or mixed with PRP-T DTaP separately, IPV separately or mixed with PRP-T As previously or in 5-valent combination vaccine In 5 valent combination vaccines

Immunisation schedule 3, 5, 12 months 3, 5, 12 months 3, 5, 12 months 3, 5, 12 months 3, 5, 12 months

UNITED KINGDOM

Year Pre 1996 1996

Type of vaccine HBOC (Hib only) DtwP/PRP-T (some DTaP used in 2000)

Combined with DTwP

Immunisation schedule 2, 3, 4 months 2, 3, 4 months

Type of vaccine PRP-T (Hib only)

Combined with DTwP

Immunisation schedule 2, 3, 4 months

This page was last updated